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CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus

Xi He1, Kyewon Park, Haitao Wang

  • 1Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA 19111, USA.

Immunity
|March 18, 2008
PubMed
Summary

Thymic selection involves T cell receptor (TCR) signals regulating the ThPOK transcription factor. A key regulatory element silences ThPOK in CD8+ T cells, while TCR signals inactivate it for CD4+ T cell commitment.

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