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The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Related Experiment Video

Updated: Jul 6, 2026

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Published on: October 20, 2023

[Cosmetics in skin aging].

A Cohen-Letessier¹

¹35, Rue de Ponthieu, 75008, Paris, France. anny.cohen-letessier@wanadoo.fr

Annales De Dermatologie Et De Venereologie

|May 6, 2008

Summary

This summary is machine-generated.

The study explores a new active substance for anti-aging cosmetics, questioning if it represents a true revolution or a change in continuity. Modern investigations support its clinical effects, aligning with health and well-being goals.

Related Experiment Videos

Last Updated: Jul 6, 2026

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Published on: October 20, 2023

Area of Science:

Cosmetic Science
Dermatology
Anti-aging Research

Context:

The concept of 'revolution' in cosmetology is examined, contrasting historical definitions with modern advancements.
Aging cosmetology is evolving, integrating modern investigative methods to understand its effects.
There's a growing emphasis on health and well-being within the field of anti-aging.

Purpose:

To evaluate whether a new active substance constitutes a revolutionary advancement in anti-aging cosmetics.
To analyze the definition of 'revolution' in the context of cosmetic science and innovation.
To connect modern scientific investigations with the established practices of aging cosmetology.

Summary:

A novel active substance for combating skin aging is introduced, prompting a discussion on its revolutionary potential.
The study contrasts the traditional definition of revolution with its modern interpretation, suggesting 'change in continuity'.
Clinical evidence supports the efficacy of this substance, aligning with contemporary health and wellness concerns in cosmetology.

Impact:

Highlights the potential for significant advancements in anti-aging skincare.
Emphasizes the integration of scientific research in developing effective cosmetic solutions.
Underscores the shift towards a holistic approach to aging, focusing on health and personal well-being.