Related Experiment Video
Updated: Jul 6, 2026
14:32
Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
Published on: February 27, 2016
Tat-SIRT1 tango
Dalibor Blazek1, B Matija Peterlin
1Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, CA 94143-0703, USA.
Molecular Cell
|March 18, 2008
Abstract:
In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.
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