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Updated: Jul 6, 2026
09:43
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Epstein-Barr virus-associated epithelial and mesenchymal neoplasms
1Department of Pathology, Emory University Atlanta, GA 30322, USA. adeyrup@emory.edu
Human Pathology
|March 18, 2008
Summary
Epstein-Barr virus (EBV), typically harmless, can cause cancers when the host-virus balance is disrupted. This review covers EBV-associated epithelial and mesenchymal tumors.
Area of Science:
- Oncology
- Virology
- Pathology
Background:
- Epstein-Barr virus (EBV) is a widespread human herpesvirus.
- EBV usually establishes a latent, asymptomatic infection.
- In rare cases, EBV disrupts the host-virus equilibrium, leading to cancer.
Purpose of the Study:
- To review the role of Epstein-Barr virus in epithelial neoplasms.
- To examine the association of EBV with mesenchymal tumors.
- To provide an overview of EBV-associated malignancies beyond hematologic cancers.
Main Methods:
- Literature review of scientific publications.
- Analysis of case studies and epidemiological data.
- Synthesis of current knowledge on EBV oncogenesis.
Main Results:
- EBV is linked to undifferentiated nasopharyngeal carcinoma and gastric adenocarcinomas.
- EBV is implicated in EBV-associated smooth muscle tumors and follicular dendritic cell tumors.
- EBV contributes to various hematologic malignancies, including lymphomas.
Conclusions:
- EBV plays a significant role in the development of diverse epithelial and mesenchymal cancers.
- Understanding EBV's oncogenic mechanisms is crucial for targeted therapies.
- Further research is needed to elucidate EBV's role in specific tumor types.
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