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Updated: Jul 6, 2026
06:34
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Thresholds in the relationship between mortality and left ventricular hypertrophy defined by electrocardiography
Edward P Havranek1, Caroline D B Emsermann, Desiree N Froshaug
1Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204-4507, USA.ehavrane@dhha.org
Journal of Electrocardiology
|March 18, 2008
Summary
New electrocardiographic criteria for left ventricular hypertrophy (LVH) were developed using mortality data. These novel criteria show promise for better clinical risk assessment and patient outcomes.
Area of Science:
- Cardiology
- Medical Diagnostics
- Public Health
Background:
- Current electrocardiographic (ECG) criteria for left ventricular hypertrophy (LVH) rely on autopsy or echocardiography.
- LVH criteria validated against mortality data may offer greater clinical relevance.
Purpose of the Study:
- To identify ECG measures that predict 5-year survival.
- To establish mortality-based thresholds for LVH diagnosis.
Main Methods:
- Utilized data from the Third National Health and Nutrition Examination Survey (NHANES III).
- Selected ECG measures discriminating between survivors and non-survivors at 5 years.
- Employed regression techniques to identify voltage thresholds and compared survival rates.
Main Results:
- Cornell voltage, Cornell product, and Novacode index demonstrated discriminative power for mortality.
- The Novacode index showed significant associations with 5-year all-cause and cardiovascular mortality, independent of systolic blood pressure.
- Identified thresholds for these ECG measures in relation to mortality risk.
Conclusions:
- ECG criteria for LVH validated against mortality data are potentially clinically useful.
- This approach may enhance the diagnostic and prognostic value of ECG in identifying LVH.
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