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Iron(III) complexes: preparation, characterization, antibacterial activity and DNA-binding.

Pramod B Pansuriya1, M N Patel

  • 1Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.

Journal of Enzyme Inhibition and Medicinal Chemistry
|March 18, 2008
PubMed
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New iron(III) complexes with ciprofloxacin and Schiff bases exhibit potent antibacterial activity and DNA inhibition. These coordination compounds show promise for therapeutic applications against various bacterial infections.

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Area of Science:

  • Coordination Chemistry
  • Medicinal Chemistry
  • Materials Science

Background:

  • Quinolones, such as ciprofloxacin, are established broad-spectrum antibiotics.
  • Schiff bases are versatile ligands with diverse biological activities.
  • Iron complexes are explored for their catalytic and therapeutic potential.

Purpose of the Study:

  • To synthesize and characterize novel iron(III) complexes incorporating ciprofloxacin and Schiff bases.
  • To evaluate the antibacterial and antifungal efficacy of these new compounds.
  • To investigate the DNA binding and inhibitory properties of the synthesized iron complexes.

Main Methods:

  • Coordination synthesis of iron(III) complexes.
  • Characterization using elemental analysis, magnetic measurements, thermogravimetric analysis (TGA), IR, UV-VIS, 1H NMR, and 13C NMR spectroscopy.
  • In vitro antibacterial and antifungal assays.
  • DNA inhibition assays.

Main Results:

  • Successful synthesis of six-coordinated dimeric distorted octahedral iron(III)-quinolone complexes.
  • Compounds demonstrated significant antibacterial activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Serratia marcescens.
  • No significant antifungal activity was observed against Aspergillus Niger, Aspergillus flavus, and Lasiodiplodia theobromae.
  • Effective inhibition of sperm herring DNA was observed for all synthesized compounds.

Conclusions:

  • The synthesized iron(III) complexes possess notable antibacterial properties and DNA inhibitory effects.
  • These findings suggest potential applications of these novel coordination compounds in antimicrobial therapies.
  • Further research is warranted to explore their mechanism of action and in vivo efficacy.