Infusion reactions triggered by monoclonal antibodies treating solid tumors

Area of Science:

• Oncology
• Immunotherapy
• Pharmacology

Background:

• Monoclonal antibodies (mAbs) are increasingly utilized as a standard of care in oncology due to their targeted therapeutic advantages.
• While generally well-tolerated, a significant concern with mAb therapy is the potential for infusion reactions, which can vary in severity.

Observation:

• Infusion reactions represent a major health issue associated with monoclonal antibody treatments.
• These reactions necessitate vigilant monitoring and prompt management by healthcare professionals.

Findings:

• Oncology nurses play a critical role in the proactive monitoring, assessment, and management of infusion reactions during mAb therapy.
• Nurses are essential in developing and implementing protocols for addressing infusion reactions effectively.

Implications:

• Effective management of infusion reactions is crucial for patient safety and maximizing the benefits of mAb therapy.
• Establishing strong partnerships between nurses, patients, and caregivers enhances the safe administration and tolerability of monoclonal antibodies.