Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipoic acid supplementation and endothelial function.

J-C Tardif1, E Rhéaume

  • 1Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada. jean.claude.tardif@icm-mhi.org

British Journal of Pharmacology
|March 18, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of clonal hematopoiesis on cardiovascular outcomes in cancer patients of the UK Biobank.

ESMO open·2025
Same author

Cross-sectional and longitudinal Biomarker extraction and analysis for multicentre FLAIR brain MRI.

Neuroimage. Reports·2025
Same author

FLAIR MRI biomarkers of the normal appearing brain matter are related to cognition.

NeuroImage. Clinical·2022
Same author

Apolipoprotein A-I proteolysis in aortic valve stenosis: role of cathepsin S.

Basic research in cardiology·2018
Same author

Beneficial Effects of High-Density Lipoproteins on Acquired von Willebrand Syndrome in Aortic Valve Stenosis.

Thrombosis and haemostasis·2018
Same author

Increase in coronary atherosclerosis severity and the prevalence of coronary artery mixed plaques in patients with psoriasis.

The British journal of dermatology·2016
Same journal

Peripheral targets for neuropathic pain.

British journal of pharmacology·2026
Same journal

Therapeutic potential of liver X receptor agonist GW3965 in preserving myelin integrity following traumatic brain injury.

British journal of pharmacology·2026
Same journal

The role of protein arginine methyltransferases in sickle cell-mediated neurovascular impairments in mice.

British journal of pharmacology·2026
Same journal

β-Cyclodextrin inclusion enhances the pro-resolving effects of the annexin A1 mimetic Ac2-26 in a mouse model of antigen-induced arthritis.

British journal of pharmacology·2026
Same journal

Ursodeoxycholic acid inhibits platelet activation and thrombosis via TREM2: Evidence from mouse models and human studies.

British journal of pharmacology·2026
Same journal

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery.

British journal of pharmacology·2026
See all related articles

Lipoic acid supplementation improved endothelial function in aged rats by enhancing nitric oxide synthase and Akt phosphorylation. This suggests lipoic acid may help prevent cardiovascular diseases.

Area of Science:

  • Cardiovascular Science
  • Pharmacology
  • Biochemistry

Background:

  • Endothelial dysfunction is a key factor in atherosclerosis development, linked to cardiovascular risk factors.
  • Aging exacerbates endothelial dysfunction, contributing to cardiovascular disease progression.

Purpose of the Study:

  • To investigate the effects of lipoic acid on endothelial function in aged rats.
  • To explore the molecular mechanisms underlying lipoic acid's impact on endothelial cells.

Main Methods:

  • Short-term lipoic acid treatment administered to aortic rings from old rats.
  • Analysis of nitric oxide synthase (NOS) and Akt phosphorylation levels.
  • Assessment of phosphatase PPA2 activity and endothelial ceramide levels.
  • Measurement of neutral sphingomyelinase activity and glutathione levels.

Related Experiment Videos

Main Results:

  • Lipoic acid improved endothelial function in aged rat aortic rings.
  • Supplementation restored age-related decreases in NOS and Akt phosphorylation.
  • Lipoic acid reduced PPA2 activity and endothelial ceramide levels.
  • Decreased neutral sphingomyelinase activity was observed, linked to increased glutathione.

Conclusions:

  • Lipoic acid demonstrates favorable antioxidant, anti-inflammatory, and metabolic effects on endothelial cells.
  • These findings support further research into lipoic acid for cardiovascular disease prevention and treatment.
  • The study highlights lipoic acid's potential to mitigate age-related endothelial dysfunction.