Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Precipitation Reactions03:10

Precipitation Reactions

In a precipitation reaction, aqueous solutions of soluble salts react to give an insoluble ionic compound – the precipitate. The reaction occurs when oppositely charged ions in solution overcome their attraction for water and bind to each other, forming a precipitate that separates out from the solution. Since such reactions involve the exchange of ions between ionic compounds in aqueous solution, they are also referred to as double displacement, double replacement, exchange reactions, or...
Acid Halides to Amides: Aminolysis01:07

Acid Halides to Amides: Aminolysis

Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN101:14

Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1

Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo, or cyano...
Preparation of 1° Amines: Azide Synthesis01:22

Preparation of 1° Amines: Azide Synthesis

Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does today's workload predict tomorrow's stress, fatigue, and other strain states? Exploring directionality in daily dynamics.

Ergonomics·2026
Same author

Sexual Harassment at Work and Its Different Facets: Age and Gender Differences in the Post-#Metoo Era.

Journal of child sexual abuse·2026
Same author

Survivorship and Clinical Outcomes up to Six Years After Combined Patellofemoral and Unicondylar Knee Arthroplasty.

Arthroplasty today·2026
Same author

A mobile device-based ecological momentary assessment in adolescents and young adults with diabetes: a systematic review and meta-analysis.

Diabetes research and clinical practice·2026
Same author

Working from Home: Hybrid and Predominantly Home-Based Work in Relation to Work Environment, Job Satisfaction, and Health.

International journal of environmental research and public health·2026
Same author

Pathways from cultural and economic stressors to mental and behavioral health risks in Hispanic youth: The roles of perceived stress and multicultural hassles.

The American journal of orthopsychiatry·2026
Same journal

A<sub>3</sub>Zr<sub>2</sub>(PS<sub>4</sub>)(P<sub>2</sub>S<sub>7</sub>)<sub>2</sub> (A = K, Rb, Cs) Synthesized by the Metal Oxide-Boron-Chalcogen Routine: A Series of Zirconium-Based Thiophosphate Nonlinear Optical Crystals Featuring PS<sub>4</sub> Tetrahedron and P<sub>2</sub>S<sub>7</sub> Dimer.

Inorganic chemistry·2026
Same journal

A Vapor-Liquid Interface Reaction Leading to the Isolation of an "Oxo-Rich" {Mo<sub>36</sub>} Polyoxometalate Compound for Proton Conductivity Studies.

Inorganic chemistry·2026
Same journal

Spatial Arrangement of Porphyrin-Eu(III) Ions on Apatite Nanoparticles.

Inorganic chemistry·2026
Same journal

Controlling Spin States in Metallosupramolecular Iron(II) Grid Architectures through Light, Temperature, and Protonation.

Inorganic chemistry·2026
Same journal

Overall Water-Splitting Enabled by Bifunctional NiPd/Pd Heterodimer Fabricated via In Situ Etching-Growth Route.

Inorganic chemistry·2026
Same journal

Luminescent Ir<sup>III</sup>-Au<sup>I</sup> Heterobimetallic Complex with a Carbene Bridging Ligand.

Inorganic chemistry·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
10:14

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

Published on: May 16, 2014

Liquid azide salts.

Stefan Schneider1, Tommy Hawkins, Michael Rosander

  • 1Space and Missile Propulsion Division, 10 East Saturn Boulevard, Air Force Research Laboratory, Edwards Air Force Base, CA 93524, USA. stefan.schneider@edwards.af.mil.

Inorganic Chemistry
|March 19, 2008
PubMed
Summary
This summary is machine-generated.

New ionic liquid azides derived from amino-triazoles were synthesized. These novel compounds exhibit low melting points, enhanced thermal stability, and negligible volatility due to quaternary nitrogen, distinguishing them from traditional salts.

More Related Videos

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
09:44

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
10:14

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

Published on: May 16, 2014

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
09:44

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

Area of Science:

  • Materials Science
  • Organic Chemistry
  • Physical Chemistry

Background:

  • Ionic liquids (ILs) are salts with low melting points, offering unique solvent properties.
  • Traditional ILs often involve protonation, limiting stability.
  • Azide functional groups are energetic and can be incorporated into novel molecular structures.

Purpose of the Study:

  • To synthesize and characterize novel ionic liquid azides.
  • To investigate the structural and physical properties of these new compounds.
  • To explore the potential of amino-triazole derivatives in creating stable, low-volatility ILs.

Main Methods:

  • Synthesis of azidoethyl, alkyl, and alkenyl substituted 1,2,4- and 1,2,3-amino-triazoles.
  • Characterization of synthesized compounds using various physical and structural analyses.
  • Evaluation of melting points, thermal stability, and volatility.

Main Results:

  • Successful preparation of novel ionic liquid azides from amino-triazole precursors.
  • All synthesized salts exhibited melting points below 100°C.
  • The presence of quaternary nitrogen in the triazole ring conferred significant thermal stability and negligible volatility.

Conclusions:

  • Novel ionic liquid azides based on amino-triazole frameworks were successfully synthesized.
  • These compounds represent a new class of ILs distinct from simple protonated salts.
  • The unique structure offers potential for applications requiring thermally stable and non-volatile ionic liquids.