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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing

F Emmerich1, C Schönemann, L Galicki

  • 1Center for Tumor Medicine, Institute for Transfusion Medicine, Charité University Medicine, Berlin, Germany. florian.emmerich@charite.de

Tissue Antigens
|March 19, 2008
PubMed

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...