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Updated: Jul 6, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Primary multifocal osseous Hodgkin's lymphoma.

Clare R Langley¹, Simon J W Garrett, Jill Urand

¹Orthopaedic Department, Basingstoke and North Hampshire Foundation Trust, Aldermaston Road, Basingstoke, Hampshire, RG24 9NA, UK. clarelangley@hotmail.com

World Journal of Surgical Oncology

|March 19, 2008

Summary

This case study reports the youngest known child diagnosed with Primary Multifocal Osseous Hodgkin's Lymphoma. The rare bone cancer mimicked other conditions, highlighting diagnostic challenges.

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Area of Science:

Pediatric Oncology
Hematology
Skeletal Oncology

Background:

Hodgkin's disease (HD) typically presents as painless lymph node enlargement, with systemic symptoms and bone involvement being uncommon at diagnosis.
Primary osseous involvement in pediatric Hodgkin's disease is exceptionally rare.
Early diagnosis of HD is crucial for effective treatment outcomes.

Observation:

A seven-year-old boy presented with sternal swelling, a rare initial symptom of Hodgkin's disease.
Investigations revealed multifocal osseous deposits in the L1 vertebra, left sacroiliac joint, and right acetabulum.
The patient's presentation was atypical for pediatric Hodgkin's disease.

Findings:

The case represents Primary Multifocal Osseous Hodgkin's Lymphoma in a pediatric patient.
Diagnostic imaging and histology confirmed bone involvement as the primary manifestation.
The patient's age makes this the youngest reported case of this condition.

Implications:

The varied presentation of osseous Hodgkin's lymphoma can mimic other conditions like Tuberculosis, complicating diagnosis.
Increased awareness of rare presentations is vital for timely and accurate diagnosis in pediatric oncology.
This case underscores the importance of considering rare diagnoses in pediatric patients with bone lesions.