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Related Experiment Videos

Naftifine: a review.

Aditya K Gupta1, Jennifer E Ryder, Elizabeth A Cooper

  • 1Department of Medicine, Sunnybrook and Women's College Health Science Center, University of Toronto, ON. agupta@execulink.com

Journal of Cutaneous Medicine and Surgery
|March 19, 2008
PubMed
Summary
This summary is machine-generated.

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Naftifine, a topical allylamine, effectively treats superficial fungal infections by disrupting ergosterol synthesis. It also offers anti-inflammatory benefits with minimal side effects, making it a reliable choice.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Naftifine is a topical allylamine used for superficial dermatomycoses.
  • It exhibits fungicidal activity against dermatophytes and activity against Candida and Aspergillus species.
  • Naftifine also demonstrates efficacy against certain bacteria.

Purpose of the Study:

  • To review the pharmacology of topical naftifine.
  • To evaluate the clinical efficacy of topical naftifine preparations.

Main Methods:

  • Literature review using PubMed (1965-2006) with the search term "naftifine."
  • Inclusion of all English-language articles on naftifine's pharmacology and clinical use.

Main Results:

  • Naftifine inhibits fungal ergosterol synthesis and causes squalene accumulation.

Related Experiment Videos

  • Demonstrated anti-inflammatory properties include reduced superoxide production and leukocyte adhesion.
  • Naftifine shows good efficacy and safety, with mild, transient local adverse events.

    • Conclusions:

    • Naftifine is a reliable, multifunctional agent for superficial infections.
    • It provides both antifungal action and relief from inflammation.