Onychomycosis in Diabetics: A Common Infection with Potentially Serious Complications
Aditya K Gupta1,2, Amanda Liddy1, Lee Magal3
1Mediprobe Research Inc., London, ON N5X 2P1, Canada.
Life (Basel, Switzerland)
|August 28, 2025
Summary
Onychomycosis is common in diabetics, increasing risks of infections and foot problems. Early diagnosis and tailored treatments, including antifungals and hygiene, are vital for managing this nail condition.
Area of Science:
- Dermatology
- Endocrinology
- Infectious Diseases
Background:
- Onychomycosis is a frequent complication in diabetic individuals.
- It elevates the risk of secondary infections, foot ulcers, and amputation.
- Prevalence is linked to age, vascular disease, glycemic control, neuropathy, and foot care.
Purpose of the Study:
- To review the epidemiology, diagnosis, and treatment of onychomycosis in diabetic patients.
- To highlight the importance of individualized care for this high-risk population.
Main Methods:
- Literature review summarizing current knowledge on onychomycosis in diabetes.
- Analysis of contributing factors, diagnostic approaches, and therapeutic strategies.
Main Results:
- Diabetics face higher risks of onychomycosis, often with mixed infections (e.g., Candida).
- Systemic antifungals (terbinafine, itraconazole) are first-line for moderate-severe cases.
- Topical agents (efinaconazole, tavaborole) and adjunctive measures are crucial for specific patient groups and recurrence prevention.
Conclusions:
- Individualized treatment plans are essential due to comorbidities and drug interactions.
- Prompt diagnosis and intervention are key to preventing severe complications.
- Comprehensive management, including patient education, improves outcomes for diabetic onychomycosis.
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