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Updated: Jun 26, 2026
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Monotherapy with Biologics for Generalized Pustular Psoriasis: A Systematic Review of Comparative Interventional
Aditya K Gupta1,2, Mary A Bamimore2, Tong Wang2
1Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Medical Sciences (Basel, Switzerland)
|June 25, 2026
Summary
Biologic therapies effectively treat generalized pustular psoriasis (GPP), a severe skin condition. Interleukin (IL)-36 inhibitors offer rapid symptom relief, while other biologics provide durable disease control and improved quality of life.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disorder.
- Limited evidence exists on the comparative effectiveness of GPP treatments.
- Biologic therapies are increasingly used for GPP management.
Purpose of the Study:
- To systematically review and synthesize comparative interventional therapies for GPP.
- To explore the relative effectiveness of biologics in GPP using exploratory network meta-analyses (NMAs).
Main Methods:
- Comprehensive literature searches in PubMed and EMBASE for comparative interventional studies on GPP biologics.
- Narrative synthesis of identified studies.
- Exploratory Bayesian network meta-analyses (NMAs) on a subset of studies.
Main Results:
- Eleven studies met inclusion criteria; data from four were used for NMAs.
- Various biologics demonstrated effectiveness in GPP treatment.
- Interleukin (IL)-36 inhibitors showed rapid pustular clearance and reduced flare frequency.
- IL-17, IL-23, TNF, and IL-12/23 inhibitors achieved high response rates and durable control.
- Exploratory NMAs suggested relative effectiveness for IL-17 and IL-36 inhibitors, but methodological limitations hindered conclusive inferences.
Conclusions:
- Biologic therapies offer significant clinical benefits for patients with GPP.
- Narrative syntheses underscore the need for future quantitative syntheses to confirm findings.
- Further research with robust methodologies is required to establish definitive treatment hierarchies.
