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Updated: Jul 6, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
Syphilis: the international challenge of the great imitator
Genevieve P Domantay-Apostol1, Evangeline B Handog, Maria Teresita G Gabriel
1Section of Dermatology, Research Institute for Tropical Medicine-Department of Health, Filinvest Corporate, Alabang, Muntinlupa City, Metro Manila, Philippines. gen_domantay@yahoo.com
Abstract:
Syphilis is a systemic disease caused by the spirochete Treponema pallidum. The name of this ancient but pervasive infection is proverbial to health care providers. The worldwide recognition of this term, however, argues with the intricacy of the disease in addition to the diagnostic and therapeutic challenges that persistently affect the global control of syphilis up to the present. This article focuses on the varied presentations of the infection, earning the title the "great imitator." The article also tackles other significant concerns regarding this malady.
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