Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prostate-Specific Antigen Screening Patterns and Metastatic Prostate Cancer in US Veterans.

JAMA network open·2026

Same author

Reproductive Planning and Preconception Counseling in Kidney Disease (REPKID):A Cross-Sectional Survey.

Kidney medicine·2026

Same author

Frailty and Quality of Life in Low-Income, Uninsured Men With Prostate Cancer.

Urology·2026

Same author

Survivor-identified barriers and facilitators to acute phase recovery following radical cystectomy.

Urologic oncology·2026

Same author

Real-world genetic testing data of ovarian cancer patients: Informing counseling and risk reduction in patients over age seventy.

Gynecologic oncology·2026

Same author

Clinician Perspectives on Integrating Mobile Sensor Data Into Cancer Care: Mixed Methods Study.

JMIR cancer·2026

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Benefit finding in response to BRCA1/2 testing.

Carissa A Low¹, Julienne E Bower, Lorna Kwan

¹Department of Psychology, UCLA, Los Angeles, CA 90095-1563, USA. carissal@ucla.edu

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine

|March 19, 2008

Summary

This summary is machine-generated.

Genetic testing for BRCA1/2 mutations can lead to positive life changes, especially for cancer survivors. Benefit finding was linked to distress and coping strategies.

More Related Videos

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

Related Experiment Videos

Last Updated: Jul 6, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

Area of Science:

Psychological impact of genetic testing
Cancer genetics and survivorship

Background:

Genetic testing for BRCA1/2 mutations can cause distress.
The potential for positive psychological changes from this testing is understudied.

Purpose of the Study:

Examine the link between BRCA1/2 mutation status, cancer history, and benefit finding (BF).
Investigate distress and coping strategies as predictors of benefit finding.

Main Methods:

108 women undergoing BRCA1/2 genetic testing completed questionnaires on distress, coping, and BF.
BRCA1/2 status and personal cancer history were determined via genetic tests and interviews.

Main Results:

Benefit finding varied widely; some reported significant positive life changes.
Mutation carriers with a prior cancer diagnosis reported higher benefit finding.
Distress and approach-oriented coping were positively associated with benefit finding.

Conclusions:

Positive life changes are possible following BRCA1/2 genetic testing, particularly for cancer survivors.
Approach-oriented coping mediates the relationship between carrier status, cancer history, and benefit finding.