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Recurrent transient global amnesia with intrathecal baclofen
Lucinda A Grande1, John D Loeser, Ali Samii
1Department of Anesthesiology, Box 356540, University of Washington School of Medicine, Seattle, WA 98195, USA. cgrande@u.washington.edu
Anesthesia and Analgesia
|March 20, 2008
Summary
Intrathecal baclofen treatment for dystonia can cause recurrent transient global amnesia, a rare form of memory loss. Fludrocortisone and nitroglycerin helped manage these baclofen-induced amnesia episodes.
Area of Science:
- Neurology
- Pharmacology
Background:
- Intrathecal baclofen is used for generalized dystonia.
- Baclofen-induced memory impairment is rare in humans, though established in rodents.
Observation:
- A patient on intrathecal baclofen developed frequent episodes of anterograde amnesia.
- These episodes met criteria for transient global amnesia and were dose-dependent.
Findings:
- Fludrocortisone reduced the frequency of amnesia spells.
- Sublingual nitroglycerin prevented and terminated these episodes.
Implications:
- This case highlights a rare side effect of intrathecal baclofen.
- It suggests potential therapeutic strategies for baclofen-associated amnesia.
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