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ACUTE DEFEROXAMINE-INDUCED RETINOPATHY
Emilie Jomaa1, Felix Blaison2, Marie-Noëlle Delyfer1,3
1Department of Ophthalmology, Bordeaux University Hospital, F-33000 Bordeaux, France.
Purpose:
To report a case of acute retinopathy in a 65-year-old woman secondary to the administration of only five subcutaneous infusions of deferoxamine.
Methods:
Clinical findings and multimodal imaging (color fundus photography, optical coherence tomography, and fundus autofluorescence) in a patient with acute deferoxamine-induced retinopathy.
Results:
The patient developed retinal toxicity after only five cycles of standard-dose subcutaneous deferoxamine. Immediate drug discontinuation was recommended, and the patient was re-examined six weeks later with a functional and anatomical improvement.
Conclusions:
and importance: This case highlighted the risk of deferoxamine-induced retinopathy, even after a very short subcutaneous administration at a standard dose. Early detection is essential, as immediate treatment discontinuation allows a good visual recovery in most cases.
