Related Experiment Video
Updated: Oct 17, 2026
Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
Published on: September 11, 2013
Bilateral Retinal Detachment after prophylactic laser therapy in Knobloch Syndrome
Caio A Silva1, Maria Frasson, Joziele S Lima
1Federal University of Minas Gerais, Belo Horizonte - Brazil.
Purpose:
Knobloch Syndrome (COL18A1-related) is a rare inherited vitreoretinopathy characterized by early-onset high myopia, regmatogenous retinal detachment and occipital skull and cutaneous defects. Although prophylactic retinal procedures have been proposed for related vitreoretinopathies, data supporting their use in Knobloch syndrome is scarce.
Methods:
Case Report.
Results:
An 8-year-old girl with genetically confirmed Knobloch syndrome who developed bilateral rhegmatogenous retinal detachment seven days after prophylactic laser therapy performed in a single-session bilaterally. Ultrawide-field retinography revealed bilateral inferotemporal retinal detachment associated with peripheral punched-out lesions. The patient underwent prompt sequential scleral buckle surgery with cryopexy and subretinal fluid drainage as indicated. Both retinas were successfully reattached and visual acuity returned to baseline values in the early postoperative period.
Conclusion:
This case highlights limited evidence supporting laser prophylaxis in Knobloch syndrome and the importance of cautious, individualized decision-making as well as the need for further research to recommend for or against prophylaxis in this syndrome.
