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Related Experiment Video

Updated: Jul 6, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Deteriorating glucose tolerance status is associated with left ventricular dysfunction--the Hoorn Study.

R M A Henry¹, W J Paulus, O Kamp

¹Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, the Netherlands.

The Netherlands Journal of Medicine

|March 20, 2008

Summary

Type 2 diabetes (DM2) significantly increases the risk of systolic and diastolic heart failure. This study found DM2 independently associated with a 2.0-fold greater risk of systolic dysfunction and a 2.4-fold greater risk of diastolic dysfunction.

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Published on: April 8, 2013

Area of Science:

Cardiology
Endocrinology
Diabetology

Background:

Type 2 diabetes (DM2) is linked to increased heart failure risk.
Mechanisms include hypertension, obesity, impaired arterial function, and metabolic cardiomyopathy.
Left ventricular systolic dysfunction (SDF) and diastolic dysfunction (DDF) are proximate causes of heart failure.

Purpose of the Study:

To investigate the association between glucose tolerance status and left ventricular systolic and diastolic dysfunction.
To determine if type 2 diabetes independently predicts systolic and diastolic dysfunction.

Main Methods:

Population-based cohort study (n=746) with normal glucose metabolism (NGM), impaired glucose metabolism (IGM), and DM2 groups.
Left ventricular echocardiogram to assess ejection fraction for SDF and specific parameters for DDF.
Statistical analysis adjusted for age, sex, hypertension, BMI, cardiovascular disease, and albuminuria.

Main Results:

DM2 prevalence was 30% for SDF and 47% for DDF, significantly higher than NGM and IGM groups (P<0.001).
Adjusted analysis showed DM2 independently associated with 2.04-fold risk of SDF and 2.42-fold risk of DDF.
IGM was not significantly associated with SDF, but showed a limited association with DDF via the E/A ratio.

Conclusions:

Type 2 diabetes is an independent risk factor for both systolic and diastolic left ventricular dysfunction.
These findings help explain the elevated heart failure risk in individuals with DM2.
Impaired glucose metabolism showed a weaker association with diastolic dysfunction, primarily linked to the E/A ratio.