Related Experiment Video
Updated: Jul 6, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
Association study of serotonin system genes in childhood-onset mood disorder
Sajid A Shaikh1, John Strauss, Nicole King
1Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada.
Background:
The serotonin system has been implicated in neuropsychiatric disorders, including mood disorders.
Methods:
We investigated polymorphisms in two serotonin-receptor genes, HTR1B and HTR2A, and the serotonin transporter (SLC6A4) in two independent samples of patients with childhood-onset mood disorders (COMD): 203 patients from Pittsburgh, USA with matched controls and 448 small families from Hungary.
Results:
Case-control and family-based analyses showed no association between COMD and any of the studied polymorphisms (all P values >0.05). Haplotype analysis of SLC6A4 was also negative in both samples.
Conclusions:
Overall, the examination of genetic variants at the HTR1B, HTR2A, and SLC6A4 loci indicated no association between the selected polymorphisms and COMD.
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Psychological and Sociocultural Causes of Schizophrenia
Sex Linked Disorders

