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[The glial fibrillary acidic protein].
1INSERM U-134, Hôpital de la Salpêtrière, Paris.
Presse Medicale (Paris, France : 1983)
|September 21, 1991
Summary
Glial fibrillary acidic protein (GFAP) is a key marker for astrocytes in the central nervous system. Its cellular specificity and abundance make it invaluable for studying glial cell differentiation in health and disease.
Area of Science:
- Neuroscience
- Cell Biology
- Biochemistry
Context:
- Glial fibrillary acidic protein (GFAP) has been extensively studied for two decades.
- GFAP is abundant in the central nervous system.
- GFAP is a highly specific marker for astrocytes.
Purpose:
- To highlight the significance of GFAP in biological research.
- To underscore its utility in tracking glial cell differentiation.
- To emphasize its role in neuropathology and neuro-oncology.
Summary:
- GFAP is a widely recognized astrocyte marker due to its abundance and specificity.
- It serves as a crucial tool for monitoring normal and pathological glial cell development.
- Research on GFAP spans normal differentiation, animal models, and human diseases.
Impact:
- GFAP's discovery has spurred over 500 publications.
- It is indispensable for research in neuropathology and neuro-oncology.
- GFAP facilitates understanding of astrocyte function and dysfunction.