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Updated: Jul 6, 2026
06:23
Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
Published on: November 21, 2025
[Renal complication in tuberous sclerosis complex].
Maria Szczepańska1, Krystyna Szprynger, Grzegorz Winiarski
1Z Katedry i Kliniki Pediatrii, Nefrologii i Endokrynologii Dzieciecej, Slaskiego Uniwersytetu Medycznego w Katowicach dializy_dzieciece_zabrze@poczta.onet.pl
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|March 21, 2008
Summary
Tuberous Sclerosis Complex (TSC) can cause severe kidney problems, including polycystic kidney disease and renal failure. Early detection and management of nephrological complications are crucial for patients with TSC.
Area of Science:
- Nephrology
- Genetics
- Pediatrics
Background:
- Tuberous Sclerosis Complex (TSC) is a genetic disorder.
- Nephrological complications are common in TSC.
- Familial TSC cases highlight genetic inheritance patterns.
Observation:
- Two pediatric cases of familial TSC are presented.
- An 18-year-old female exhibited polycystic kidney disease, end-stage renal failure, epilepsy, intellectual disability, CNS calcifications, and skin abnormalities.
- A 10.5-year-old male showed hyperechoic renal cortex with normal renal function, alongside other TSC features.
Findings:
- The female patient experienced asymptomatic acute bleeding into a renal cyst and subcapsular hematoma.
- Life-threatening bleeding necessitated bilateral nephrectomy in the female patient.
- Renal morphology in the male patient indicated potential early-stage kidney involvement.
Implications:
- This review underscores the significant risk of severe nephrological complications in TSC.
- Aggressive monitoring and timely intervention are vital for managing TSC-related kidney disease.
- Understanding familial TSC patterns aids in predicting and managing disease progression.
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