Mucous membrane pemphigoid with oral involvement: Two cases reports

These cases present a fifty-four- and sixty-four-year-old females, one of whom had the second episode of the disease. Clinical and cytological examinations of the oral lesions were performed, and the Oral Health Impact Profile-14 (OHIP-14) questionnaire was administered. Additionally, histopathological examination and direct immunofluorescence microscopy were conducted on the patient's biopsied lesions. This article presents two case reports of patients with mucous membrane pemphigoid involving the oral cavity. As an autoimmune bullous disease, mucous membrane pemphigoid is often characterized by oral manifestations without skin lesions and typically follows a chronic course. In addition to standard clinical and cytological observations, histopathology and direct immunofluorescence are essential for confirming the diagnosis. Because recurrence is common, identifying potential triggers is vital to minimizing flare-ups. Clinical management includes meticulous oral hygiene, topical anesthetics, corticosteroids, and antimicrobial mouthwashes. The authors believe these cases will provide valuable insights for dentists and encourage the early diagnosis and treatment of this condition in routine practice.