[Coronary reserve in treated hypertension with persistent left ventricular hypertrophy]

It has been demonstrated that coronary reserve (CR) is impaired in hypertensive patients with left ventricular hypertrophy and normal epicardial coronary arteries. The present study was undertaken in order to determine if CR returns to normal level after antihypertensive therapy in patients with persistent left ventricular hypertrophy, when the decrease of arterial blood pressure induces a reduction of LV wall stress (LVWS). In 26 patients with normal coronary arteriography, end-diastolic wall thickness (EDWT), LV mass (LVM) and peak systolic LVWS were determined on 30 degrees right anterior oblique LV angiography with simultaneous recording of LV pressure (micromanometer). Coronary flow velocity was measured with a coronary doppler catheter before and after a maximally vasodilating dose of intracoronary papaverine (12 mg). The study group included 6 untreated (G1) and 7 treated (G2) hypertensive patients with LV hypertrophy, and 13 control subjects (C). The peak-to-resting coronary flow velocity ratio (P/R) and a minimal coronary vascular resistance index (MCVRI) calculated as the quotient of mean aortic pressure at peak flow velocity to peak flow velocity and mean aortic pressure at resting flow velocity to resting flow velocity were assessed. Results evidenced that in hypertensive patients with LV hypertrophy, levels of P/R and MCVRI were similar in treated and untreated groups. Thus, in treated patients P/R remained lower and MCVRI remained higher than in control subjects despite the normalization of arterial pressure that resulted in a low peak systolic LVWS. [table: see text]

this study demonstrates that anti-hypertensive therapy does not restore a normal coronary vascular reserve in patients with persistent LV hypertrophy.(ABSTRACT TRUNCATED AT 250 WORDS)