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Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
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Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing

Akeel Alisa1, Sandra Boswell, Ansar A Pathan

  • 1Department of Medicine, Institute of Hepatology, University College London, London, UK.

Journal of Immunology (Baltimore, Md. : 1950)
|March 21, 2008
PubMed
Summary

Tumor antigens like alpha-fetoprotein (AFP) can expand tumor-specific T cells that produce TGF-beta, promoting immune evasion. These regulatory T cells (Tregs) inhibit anti-tumor responses in hepatocellular carcinoma patients.

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