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Related Experiment Videos

High-resolution scanning surface-plasmon microscopy.

M G Somekh1, S Liu, T S Velinov

  • 1School of Electrical and Electronic Engineering, University Park, Nottingham NG7 2RD, UK. mike.somekh@nottingham.ac.uk

Applied Optics
|March 21, 2008
PubMed
Summary
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Surface plasmons (SPs) are sensitive to dielectric changes, enabling sensor applications. Novel microscopy techniques overcome resolution limits for enhanced biological imaging.

Area of Science:

  • Physics
  • Optics
  • Materials Science

Background:

  • Surface plasmons (SPs) are electromagnetic waves at conductor-dielectric interfaces.
  • SPs exhibit high sensitivity to changes in dielectric properties, making them valuable for sensors.
  • Microscopic applications of SPs are typically limited by lateral resolution to several micrometers.

Purpose of the Study:

  • To overcome the lateral resolution limitations of surface plasmon microscopy.
  • To demonstrate enhanced resolution in SP imaging comparable to high-numerical-aperture optical microscopy.
  • To explore the potential of ultrahigh-numerical-aperture objectives for biological imaging.

Main Methods:

  • Utilizing defocused high-numerical-aperture liquid-immersion objectives for SP imaging.

Related Experiment Videos

  • Presenting surface plasmon images to showcase achieved resolution.
  • Discussing the impact of objectives with numerical apertures exceeding 1.5.

    • Main Results:

    • Achieved lateral resolution in SP imaging comparable to high-numerical-aperture optical microscopes.
    • Demonstrated a method to surpass the micrometer-scale resolution limit in SP microscopy.
    • Provided evidence for the influence of advanced objectives on imaging capabilities.

    Conclusions:

    • Defocused high-numerical-aperture liquid-immersion objectives effectively enhance surface plasmon microscopy resolution.
    • Ultrahigh-numerical-aperture objectives hold significant promise for advancing biological imaging applications.
    • Surface plasmon microscopy, with improved optics, offers a powerful tool for nanoscale sensing and imaging.