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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
Published on: November 23, 2015
Spatial modulation microscopy for real-time imaging of plasmonic nanoparticles and cells
N Fairbairn1, R A Light, R Carter
1Institute for Life Sciences and Faculty of Physical and Applied Sciences, University of Southampton, Highfield, Southampton, UK.
Optics Letters
|August 4, 2012
Abstract:
Spatial modulation microscopy (SMM) is a technique originally developed for quantitative spectroscopy of individual nano-objects. Here, a parallel implementation of the SMM technique is demonstrated based on a line detector capable of demodulation at kHz frequencies. The capabilities of the imaging system are shown using an array of plasmonic nanoantennas and dendritic cells incubated with gold nanoparticles.

