[Leukocytic intracellular components and proantioxidative systems in HIV-infected patients]

The present study was undertaken to examine the state of intracellular components and leukocytes and the role of the lipid peroxidation (LPO) system and antioxidative defense (AOD) in the pathogenesis of HIV infection. The parameters of the enzymatic link of the antioxidative system and LPO processes and leukocytic intracellular components in 108 patients with HIV infection are presented. In the HIV-infected patients, the state of intracellular components of leukocytes showed a heterodirectional pattern. Thus, the values of myeloperoxidase and cationic protein exhibited a regular trend for a decrease with the maximum inhibition when secondary diseases occurred. The activity of acid phosphatase, glycogen and spontaneous HCT test increased with progression of the disease. The findings suggest that there are severe LPO disorders, as documented by a significant increase in its products forming at different stages of the peroxide cascade of hydroperoxides: malonic dialdehyde and dienic conjugates. The rate of LPO-AOD processes depends on the stage of the disease and the treatment performed. It is important to note that in HIV-infected patients the increased rate of LPO was followed by the considerably suppressed overall antioxidative activity of blood, catalase, and superoxide dismutase. The decrease in these parameters suggests a severe disturbance of the antioxidative system in different periods of the disease. The enhanced LPO activity in patients with HIV infection is likely to be one of the pathogenetic links of development of the disease and requires corrective therapy.