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Subcorneal pustular dermatosis: 50 years on.
S Cheng1, E Edmonds, M Ben-Gashir
1Departments of Dermatology and Histopathology, University College London Hospital, London, UK. suzanne.cheng@gmail.com
Clinical and Experimental Dermatology
|March 22, 2008
Summary
Subcorneal pustular dermatosis (SCPD), or Sneddon-Wilkinson disease, is a rare skin condition characterized by sterile pustules. While its exact cause remains unknown, dapsone is the primary treatment, with other options available.
Area of Science:
- Dermatology
- Immunology
Background:
- Subcorneal pustular dermatosis (SCPD), also known as Sneddon-Wilkinson disease, is a rare chronic sterile pustular eruption.
- First described in 1956, SCPD presents with pea-sized pustules, histologically showing subcorneal neutrophil accumulation.
Purpose of the Study:
- To review key developments in understanding Subcorneal Pustular Dermatosis (SCPD) over the last 50 years.
- To summarize the pathophysiology, associated conditions, and treatment options for SCPD.
Main Methods:
- Literature review of key developments in SCPD over the past 50 years.
- Analysis of histological findings, associated conditions, and treatment modalities.
Main Results:
- The exact pathophysiology of SCPD remains unknown, though neutrophil accumulation suggests chemoattractants like TNF-alpha.
- SCPD is associated with pyoderma gangrenosum, IgA gammopathy, multiple myeloma, and anecdotal reports of other malignancies.
- Dapsone is the preferred treatment, with alternatives including retinoids, phototherapy, and corticosteroids.
Conclusions:
- Further research is needed to elucidate the exact pathophysiology of Subcorneal Pustular Dermatosis.
- Comprehensive management strategies involving established and alternative therapies are crucial for SCPD patients.
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