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Sympathetic skin responses in multiple sclerosis.

A Saari1, U Tolonen, E Pääkkö

  • 1Department of Neurology, Oulu University Hospital, Oulu, Finland. anne.saari@ppshp.fi

Acta Neurologica Scandinavica
|March 22, 2008
PubMed
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Sympathetic skin responses (SSRs) are often abnormal in multiple sclerosis (MS) patients. Specific brain lesions, particularly in the temporal lobe, pons, and cerebellum, correlate with these sudomotor dysfunctions.

Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Sudomotor dysfunction, indicated by abnormal sympathetic skin responses (SSRs), can occur in MS patients.

Purpose of the Study:

  • To investigate the relationship between sympathetic skin responses (SSRs) and brain lesion volumes in multiple sclerosis (MS).

Main Methods:

  • Sympathetic skin responses (SSRs) were recorded in 27 MS patients and 27 healthy controls.
  • Brain lesion volumes were quantified using MRI, specifically proton density-weighted images.

Main Results:

  • Abnormal SSRs were observed in 52% of MS patients, with absence primarily in clinically severe cases.
  • Total brain lesion volume correlated with MS severity (EDSS score) and reduced SSR amplitudes in the feet.

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  • Focal lesions in the temporal lobe, pons, and cerebellum were significantly associated with abnormal SSR reflexes.

    • Conclusions:

    • Sudomotor regulation failure in MS is linked to the presence of specific focal brain lesions.
    • This suggests a correlation between MS-related neurological damage and autonomic nervous system dysfunction.