Fetal and neonatal haematological complications in monochorionic twins

Placental vascular anastomoses are almost invariably present in monochorionic (MC) placentas. These anastomoses are the essential anatomical substrate for the development of several haematological complications in MC twins, in particular twin-to-twin transfusion syndrome (TTTS). Several forms of TTTS have been described, including chronic TTTS, acute perimortem TTTS, twin anaemia-polycythaemia sequence, acute perinatal TTTS and twin reversed arterial perfusion sequence. A significant evolution in prenatal care strategies and management options for patients with TTTS has occurred during the last decade. In chronic TTTS, endoscopic laser ablation of communicating placental vessels has led to an increase in survival rates. This review analyzes the possible pathophysiologic mechanisms involved, discusses the latest findings in diagnosis, therapy and prognosis, and focuses on fetal and neonatal haematologic complications associated with the various forms of TTTS.