Related Experiment Video
Updated: Jul 6, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
PET/MRI hybrid imaging: devices and initial results
Bernd J Pichler1, Martin S Judenhofer, Hans F Wehrl
1Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Eberhard Karls University of Tübingen, Röntgenweg 13, 72076 Tübingen, Germany. Bernd.Pichler@med.uni-tuebingen.de
Combining positron emission tomography (PET) with magnetic resonance tomography (MRI) offers superior soft-tissue contrast and functional information compared to X-ray computed tomography (CT). Latest PET/MRI systems show promising results for preclinical research.
Area of Science:
- Medical Imaging
- Biomedical Engineering
Background:
- Conventional positron emission tomography (PET) combined with X-ray computed tomography (CT) offers value but limited soft-tissue contrast and high radiation dose.
- Magnetic resonance tomography (MRI) provides excellent soft-tissue contrast and functional information (e.g., fMRI, NMRS).
Purpose of the Study:
- To explore the combination of PET and MRI for advanced preclinical imaging.
- To overcome the limitations of CT in PET/CT systems.
Main Methods:
- Development of PET/MRI systems utilizing solid-state light detectors for operation in high magnetic fields.
- Comparison of PET/MRI capabilities against conventional PET/CT.
Main Results:
- Latest PET/MRI prototypes demonstrate promising results in preclinical studies.
- Successful integration of high-resolution morphology with multifunctional imaging information.
Conclusions:
- PET/MRI systems offer significant advantages over PET/CT for preclinical research.
- Advanced PET/MRI technology enables simultaneous acquisition of morphological and functional data.
Related Concept Videos
Magnetic Resonance Imaging
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

