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Updated: Jul 6, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Parent-child interactions in pediatric bipolar disorder
Lindsay S Schenkel1, Amy E West, Erin M Harral
1Pediatric Mood Disorders Program, Institute for Juvenile Research, University of Illinois at Chicago, IL, USA. lindsay.schenkel@att.net
Insights
Children with pediatric bipolar disorder (PBD) experience less warmth and more conflict in parent-child relationships. These relationship difficulties are linked to illness severity and family factors, impacting PBD treatment.
Area of Science:
- Child and Adolescent Psychiatry
- Family Psychology
- Developmental Psychopathology
Background:
- Pediatric bipolar disorder (PBD) significantly impacts children and their families.
- The quality of parent-child relationships may influence PBD symptomology and course.
- Reciprocal effects between child illness and family dynamics are crucial to understand.
Purpose of the Study:
- To investigate parent-child relationship characteristics in youth with PBD compared to controls.
- To identify factors associated with relationship difficulties in families with PBD.
- To inform targeted interventions for PBD treatment.
Main Methods:
- Maternal reports on the Parent-Child Relationship Questionnaire (PCRQ) were collected from 60 families (30 PBD, 30 controls).
- Data on child psychopathology (mania, ADHD) and parental psychopathology were assessed.
- Statistical analyses compared relationship quality and identified associated factors.
Main Results:
- Families with PBD youth reported significantly less warmth, affection, and intimacy.
- Increased quarreling and forceful punishment were observed in parent-child relationships within the PBD group.
- PBD factors like mania symptoms, ADHD comorbidity, early onset, single-parent homes, and parental mood disorders correlated with relationship difficulties.
Conclusions:
- Parent-child relationships in PBD are characterized by reduced positive affect and increased conflict.
- Specific child and family factors exacerbate these relationship challenges.
- Interventions for PBD should address parent-child relationship quality alongside symptom management.
Abstract:
Parent-child relationships may have a significant effect on illness characteristics of children with pediatric bipolar disorder (PBD), and these relationships may, in turn, be affected by the child's illness. We characterized maternal reports of parent-child relationships using the five-factor Parent-Child Relationship Questionnaire (PCRQ) in 60 families (30 PBD youth and 30 matched controls). Data on child proband and parental psychopathology were also obtained. Compared to controls, parent-child relationships in the PBD group were characterized by significantly less warmth, affection, and intimacy, and more quarreling and forceful punishment. Among PBD participants, elevated symptoms of mania, comorbid ADHD, an earlier age of illness onset, living in a single parent home, and the presence of a parental mood disorder were associated with greater parent-child relationship difficulties. These findings have implications for the development of interventions that focus on the quality of parent-child relationships, in addition to symptom management, in the treatment of PBD.
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