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Updated: Jul 6, 2026

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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
[Clinical study on acute periapical periodontitis caused by overfilling]
Yong-hai Cai1, Chang-shou Lu, Ke-xiang Huang
1Dept. of Stomatology, The Second People's Hospital of Cangnan County, Zhejiang Province, China.
Summary
Overfilling dental canals with gutta-percha points or paste can cause acute periapical periodontitis. Gutta-percha point overfilling resulted in more severe symptoms but resolved faster than paste overfilling.
Area of Science:
- Endodontics
- Dental Radiology
- Oral Pathology
Background:
- Acute periapical periodontitis is a common dental condition.
- Overfilling of root canal filling materials can lead to complications.
- Understanding the impact of different overfilling materials is crucial for treatment outcomes.
Purpose of the Study:
- To investigate the relationship between gutta-percha point or paste overfilling and the severity of acute periapical periodontitis.
- To compare the clinical signs and resolution times associated with gutta-percha point versus paste overfilling.
Main Methods:
- Sixty cases of acute periapical periodontitis with recent gutta-percha point and paste fillings were analyzed.
- Cases were categorized based on whether gutta-percha points or paste overfilled the apex.
- Clinical signs were assessed, and treatment involved material removal and daily medication until resolution.
Main Results:
- Gutta-percha point overfilling (Group A) averaged 1.01 mm (mild) to 1.79 mm (severe) beyond the apex.
- Paste overfilling (Group B) averaged 2.45 mm² (mild) to 8.26 mm² (severe) beyond the apex.
- Group A showed more severe cases (21/34) than Group B (8/26), with resolution in 3.56 days versus 6.19 days for Group B.
Conclusions:
- Increased overfilling correlated with more severe clinical signs of acute periapical periodontitis.
- Gutta-percha point overfilling led to more severe symptoms compared to paste overfilling.
- Resolution time for symptoms caused by gutta-percha point overfilling was shorter.