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Updated: Jul 6, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Biocompatible water-in-oil emulsion as a model to study ascorbic acid effect on lipid oxidation
Monica Mosca1, Andrea Ceglie, Luigi Ambrosone
1Consorzio per lo sviluppo dei Sistemi a Grande Interfase, c/o Dept. Food Technology DISTAAM, Università del Molise, via De Sanctis 86100 Campobasso, Italy. mosca@unimol.it
Abstract:
A biocompatible water-in-oil (W/O) emulsion has been used as a model to study the effect of ascorbic acid (AA) on the oxidation of the oil (glycerol trioleate, GTO) continuous phase. The model system consisted of 3 wt % water dispersed in GTO containing 0.5 wt % sodium oleate (NaO)/oleic acid (OA) mixture (NaO/OA = 20/80 mol/mol %) as a stabilizer. To study the ascorbic acid effect on GTO light-promoted oxidation, we added aqueous solutions of ascorbic acid to GTO in place of distilled water. Results obtained as peroxide values show that ascorbic acid activity depends on its concentration and it is affected by the characteristics of the W/O interface. In the presence of ascorbyl palmitate (AP) or sorbitan trioleate (Span 85) in the continuous phase, ascorbic acid activity increases in the first few hours of oxidation. The effect of ascorbic acid has been related to emulsion structure by calculating characteristic parameters of the droplet size distributions by means of optical microscopy.
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