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Tinnitus treatment with memantine.

Ricardo Rodrigues Figueiredo¹, Berthold Langguth, Patricia Mello de Oliveira

¹OTOSUL-Otorrinolaringologia Sul-Fluminense. rfigueiredo@otosul.com.br

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

|March 25, 2008

Summary

Memantine did not significantly improve tinnitus symptoms compared to placebo in a clinical trial. Further research is needed to explore potential delayed effects of memantine for tinnitus management.

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Area of Science:

Neurology
Otolaryngology

Background:

Tinnitus is a prevalent condition affecting millions globally.
Current treatment options for tinnitus offer limited efficacy for many patients.

Purpose of the Study:

To investigate the efficacy and safety of memantine in managing tinnitus.
To assess memantine's impact on tinnitus-related distress using the Tinnitus Handicap Inventory (THI).

Main Methods:

A prospective, randomized, double-blind, placebo-controlled crossover study was conducted.
Sixty patients with tinnitus were randomized to receive either memantine (up to 20 mg) or placebo for 90 days, with a 30-day washout period.
The Tinnitus Handicap Inventory (THI) was used to evaluate treatment outcomes in 43 completers.

Main Results:

No statistically significant improvement in THI scores was observed with memantine compared to placebo.
A potential trend towards delayed therapeutic effects of memantine was noted.
The incidence of side effects during memantine treatment was 9.4%, necessitating treatment interruption in all affected cases.

Conclusions:

The study findings do not support the use of memantine for treating tinnitus.
Further investigation with extended observation periods is warranted to explore potential delayed effects of memantine.