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Updated: Jul 6, 2026
11:28
A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
Published on: September 9, 2015
Dalbavancin: a new lipoglycopeptide antibiotic
Jennifer Bailey1, Kelly M Summers
1School of Pharmacy, University of Maryland, Baltimore MD 21201-1142, USA.
Summary
Dalbavancin is a novel lipoglycopeptide antibiotic effective against resistant gram-positive bacteria, including MRSA. Its unique pharmacokinetics allow for once-weekly dosing, demonstrating efficacy and safety in treating skin and bloodstream infections.
Area of Science:
- Pharmacology and Infectious Diseases
Background:
- Dalbavancin is a second-generation lipoglycopeptide antimicrobial agent.
- It possesses unique pharmacokinetic properties and potent activity against Gram-positive pathogens.
Purpose of the Study:
- To review the activity, pharmacokinetics, pharmacodynamics, efficacy, safety, and formulary considerations of dalbavancin.
- To evaluate dalbavancin's role in treating resistant Gram-positive bacterial infections.
Main Methods:
- Literature review of studies on dalbavancin.
- Analysis of in vitro and in vivo data on its antimicrobial activity.
- Review of clinical trial data on efficacy and safety.
Main Results:
- Dalbavancin exhibits excellent activity against resistant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).
- It has a long half-life, enabling once-weekly intravenous administration and demonstrating superior bactericidal potency compared to vancomycin and teicoplanin.
- Clinical trials show efficacy in skin and soft-tissue infections and catheter-related bloodstream infections, with a safety profile of mild to moderate adverse events.
Conclusions:
- Dalbavancin is a safe and effective option for treating Gram-positive bacterial infections, including complicated skin infections and catheter-related bloodstream infections.
- Its enhanced activity and unique pharmacokinetics offer advantages over existing therapies.
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