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Atrial natriuretic factor: a possible new gastrointestinal regulatory peptide
C V Godellas1, W R Gower, P J Fabri
1Surgical, Laboratory, James A. Haley Veterans Hospital, Tampa, FL 33612.
Surgery
|December 11, 1991
Summary
Hypergastrinemia, induced by fundusectomy in rats, significantly elevates circulating atrial natriuretic factor (ANF) and pro-ANF levels. The duodenum appears to be the primary source of these increased ANF peptides.
Area of Science:
- Gastroenterology
- Endocrinology
- Cardiovascular Physiology
Background:
- Atrial natriuretic factor (ANF) primarily associated with cardiovascular system.
- ANF influences duodenal contractions and gastrointestinal salt/water absorption.
- Hypergastrinemia is linked to secretory diarrhea and increased peristalsis.
Purpose of the Study:
- To investigate the role of ANF in a rat model of hypergastrinemia.
- To evaluate ANF and pro-ANF levels following fundusectomy.
Main Methods:
- Sprague-Dawley rats underwent either fundusectomy or sham operation.
- Measurement of circulating and tissue levels of gastrin, ANF, and pro-ANF 1-98.
- Analysis of peptide concentrations in stomach and small intestine tissues.
Main Results:
- Fundusectomy significantly increased circulating gastrin, ANF, and pro-ANF 1-98 levels.
- Elevated ANF and pro-ANF levels correlated with increased gastrin.
- Duodenal ANF and pro-ANF 1-98 content was markedly higher in fundectomized rats compared to controls.
Conclusions:
- Hypergastrinemia induced by fundusectomy leads to increased circulating ANF and pro-ANF.
- The duodenum is identified as a potential source of elevated ANF and pro-ANF.
- These findings suggest a link between gastrin, ANF, and gastrointestinal function.