[Healing efficacy of repairing mucosa defect with heterogeneity acellular dermal matrix]

To introduce the clinical application of heterogeneity (cattle) acellular dermal matrix (ADM) in the repair of mucosa defect otolaryngology.

From October 2006 to March 2007, 12 cases of mucosa defect was repaired with heterogeneity ADM after the surgery. There were 10 males and 2 females, aged 18-76 years. Defect was caused by deflection of nasal septum in 1 case, melanoma of front and midst basalis (capillary hemangioma) in 1 case, nasal vestibule angioma (T2N2M0) in 1 case, cancer of hypopharynx (T2N1M0) in 1 case, cancer of amygdale in 3 cases (2 of T2N0M0 and 1 of T3N1M0), cervical segments esophageal carcinoma in 1 case, and cancer of larynx in 4 cases (3 of T2N0M0 and 1 of T3N1M0).

All these 12 cases were followed up for 6 months. The results of endoscope showed that heterogeneity ADM mingled with mucosa within 3 months after operation and the function was recovered. Pharynx fistula occurred in 1 case of hypopharynx cancer after the operation. After treatment of dressing change and antibiotics for 10 days, the wound healed, but after 2 months tumor recurred. All the patients were treated by radiation treatment. One case of amygdala cancer recurred and transferred to the neck after 2 months of radiation treatment. But 1 case of hypopharynx cancer died of massive haemorrhage after radiation treatment for 3 months.

Heterogeneity ADM can be easily obtained and it is a new method to repair mucosa defect. The operative procedure is easy to perform and worthwhile to be applied to clinical operation.