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Environmental heterogeneity enhances clonal interference.

Paulo R A Campos1, Pedro S C A Neto, Viviane M de Oliveira

  • 1Departamento de Física, Universidade Federal Rural De Pernambuco 52171-900, Dois Irmãos, Recife-Pe, Brazil. paulo.campos@df.ufrpe.br

Evolution; International Journal of Organic Evolution
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Summary
This summary is machine-generated.

Clonal interference (CI) in asexual microbes is influenced by gene flow and spatial variation. Low migration and high environmental heterogeneity enhance CI, impacting adaptive evolution rates.

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Area of Science:

  • Evolutionary Biology
  • Population Genetics

Background:

  • Clonal interference (CI) is a significant factor in the adaptation of large asexual populations with high mutation rates.
  • Understanding the interplay of gene flow and spatial heterogeneity is crucial for predicting microbial evolution.

Purpose of the Study:

  • To investigate how gene flow and spatial variation in selection strength affect clonal interference and adaptation in asexual populations.
  • To determine the conditions under which spatial heterogeneity enhances or diminishes the rate of adaptive evolution.

Main Methods:

  • A theoretical model of a subdivided asexual population with migration between patches.
  • Analysis of adaptation driven by new beneficial mutations with patch-dependent fitness effects.
  • Examination of the impact of varying migration rates and environmental heterogeneity levels.

Main Results:

  • Spatial variation in selection pressure alters the rate of adaptive evolution, with effects contingent on gene flow levels.
  • Low migration rates combined with high environmental heterogeneity intensify clonal interference.
  • High migration rates can lead to a higher fixation rate of adaptive mutations in heterogeneous environments.

Conclusions:

  • Gene flow and spatial heterogeneity are key modulators of clonal interference and adaptive evolution in asexual microbes.
  • Environmental heterogeneity can either enhance or counteract clonal interference depending on migration dynamics.
  • Complex interactions between migration, heterogeneity, and selection shape the evolutionary trajectories of asexual populations.