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Relationship between nutritional status and maximum inspiratory and expiratory pressures in cystic fibrosis

Bruna Ziegler1, Janice L Lukrafka, Claudine L de Oliveira Abraão

  • 1Centro Universitário Metodista Instituto Porto Alegre, Rio Grande do Sul, Brazil.

Respiratory Care
|March 28, 2008
PubMed

Insights

Nutritional status in cystic fibrosis (CF) patients does not significantly impact respiratory muscle strength, measured by maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP). This study found no correlation between nutritional status and pulmonary function in adults with CF.

Area of Science:

  • Pulmonary Medicine
  • Clinical Nutrition
  • Respiratory Physiology

Background:

  • Malnutrition is hypothesized to decrease respiratory pressure and function in cystic fibrosis (CF).
  • Understanding this relationship is crucial for managing CF patients.

Purpose of the Study:

  • To investigate the association between nutritional status and maximal respiratory pressures in adult CF patients.
  • To determine if nutritional status correlates with pulmonary function tests.

Main Methods:

  • A prospective cross-sectional study was conducted on 39 adult CF patients (age >= 16).
  • Maximal inspiratory and expiratory pressures (MIP/MEP) and spirometry (FEV1) were measured.
  • Nutritional status was assessed using BMI, triceps-skin-fold, and mid-upper-arm-muscle circumference.

Main Results:

  • No significant differences in MIP, MEP, or FEV1 were observed between normal and nutritionally depleted groups.
  • MIP and MEP showed no significant correlation with BMI or FEV1.
  • The study included 39 patients (23 female/16 male) with a mean age of 23.7 years.

Conclusions:

  • Maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) do not appear to be significantly related to nutritional status in adult CF patients.
  • These respiratory pressures also showed no significant relationship with clinical scores, chest radiograph findings, or overall pulmonary function.
Abstract

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