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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

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Angiogenesis and angiogenic inhibitors in renal cell carcinoma

Rishi Sawhney1, Fairooz Kabbinavar

  • 1Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, 10945 LeConte Avenue, Suite 2333D, Box 957059, Los Angeles, CA 90095, USA. fkabbina@mednet.ucla.edu

Current Urology Reports
|March 28, 2008
PubMed

Insights

Targeting vascular endothelial growth factor (VEGF) offers effective treatment for clear cell renal cell carcinoma (RCC). Future research aims to identify patients who best respond to these antiangiogenic therapies for improved outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Clear cell renal cell carcinoma (RCC) often involves inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene.
  • VHL gene inactivation promotes a proangiogenic state characterized by vascular endothelial growth factor (VEGF) overexpression.

Purpose of the Study:

  • To review the role of angiogenesis in RCC.
  • To summarize the efficacy of antiangiogenic therapies targeting VEGF in metastatic RCC.

Main Methods:

  • Literature review of studies on angiogenesis, VHL gene, VEGF biology, and antiangiogenic therapies in metastatic RCC.

Main Results:

  • Antiangiogenic therapies targeting VEGF have demonstrated significant clinical activity in metastatic RCC.
  • The molecular basis for targeting VEGF in RCC is well-established due to VHL gene inactivation.

Conclusions:

  • VEGF-targeting agents represent a key therapeutic strategy for metastatic RCC.
  • Further research is needed to identify patient subgroups who will benefit most from antiangiogenic therapy.

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