Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement deficiency and disease.

B P Morgan1, M J Walport

  • 1Dept of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK.

Immunology Today
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Executive Summary to the Royal Society report "COVID-19: examining the effectiveness of non-pharmaceutical interventions".

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2023
Same author

Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity.

Clinical and experimental immunology·2023
Same author

The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade.

Human molecular genetics·2021
Same author

Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex.

Thrombosis research·2016
Same author

Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis.

Journal of thrombosis and haemostasis : JTH·2015
Same author

Complement activation and expression during chronic relapsing experimental autoimmune encephalomyelitis in the Biozzi ABH mouse.

Clinical and experimental immunology·2015
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Hereditary complement deficiencies increase susceptibility to infections and immune complex diseases. Studying these conditions helps define the complement system's crucial roles in human immunity.

Area of Science:

  • Immunology
  • Human Genetics
  • Infectious Diseases

Background:

  • Complement deficiency is linked to higher rates of pyogenic infections and immune complex disorders.
  • The clinical presentation of complement deficiency varies based on the specific complement pathway affected.
  • Hereditary complement deficiencies serve as natural models to understand complement function.

Purpose of the Study:

  • To review current knowledge on human hereditary complement deficiencies.
  • To highlight the significance of these deficiencies in elucidating complement's in vivo roles.
  • To connect complement deficiencies with specific disease manifestations.

Main Methods:

  • Review of existing literature on hereditary complement deficiencies.
  • Analysis of disease spectrum in individuals with complement defects.

Related Experiment Videos

  • Correlation of complement pathway defects with clinical outcomes.

    • Main Results:

    • Complement deficiencies predispose individuals to specific types of infections.
    • The location of the complement system defect dictates the associated diseases.
    • Case studies illustrate the critical functions of complement components.

    Conclusions:

    • Understanding complement deficiencies is vital for both clinical practice and basic research.
    • These deficiencies underscore the essential role of the complement system in immune defense.
    • Further research into complement biology can lead to novel therapeutic strategies.