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Related Experiment Video

Updated: Jul 6, 2026

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

Chikungunya infection in neonates.

Gouri Rao¹, Yasmin Zakarya Khan, D S Chitnis

¹Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India. gouripassi@hotmail.com

Indian Pediatrics

|March 28, 2008

Summary

Chikungunya infection in newborns is confirmed by RNA PCR. Key symptoms observed were apnea, fever, rash, and skin hyperpigmentation.

Area of Science:

Neonatology
Infectious Diseases
Virology

Background:

Chikungunya virus (CHIKV) poses a significant threat to newborns, potentially causing severe health complications.
Early diagnosis and understanding of neonatal CHIKV presentation are crucial for timely intervention and management.

Observation:

This report details two neonates diagnosed with chikungunya infection, confirmed via ribonucleic acid polymerase chain reaction (RNA PCR).
Clinical manifestations in these infants included apnea, fever, and a distinct erythematous maculo-papular rash.
Generalized hyperpigmentation was also a notable clinical feature observed in the affected neonates.

Findings:

Neonatal chikungunya infection can present with severe respiratory distress (apnea) and dermatological signs.

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RNA PCR is a reliable method for confirming chikungunya virus infection in neonates.

The combination of fever, rash, and hyperpigmentation requires consideration for chikungunya in affected newborns.

Implications:

Increased awareness of neonatal chikungunya symptoms is vital for pediatricians and infectious disease specialists.
Prompt diagnosis can lead to improved clinical outcomes and reduced morbidity in affected infants.
Further research into the long-term effects and specific management strategies for neonatal chikungunya is warranted.