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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Gastric Motility01:16

Gastric Motility

Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...

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Related Experiment Videos

Gallbladder motility in children with chronic constipation.

Magno Cardoso Veras Neto1, Roberto Massao Yamada, Elizete Aparecida Lomazi da Costa Pinto

  • 1Department of Pediatrics, Pediatric Gastroenterology Division, Universidade Estadual de Campinas, São Paulo, Brazil. elizcostapinto@terra.com.br

Journal of Pediatric Gastroenterology and Nutrition
|March 28, 2008
PubMed
Summary

Children with severe constipation show impaired gallbladder motility. This gallbladder dysfunction may be a factor in functional constipation, impacting pediatric gastroenterology care.

Related Experiment Videos

Area of Science:

  • Pediatric Gastroenterology
  • Digestive System Physiology
  • Medical Imaging

Background:

  • Functional constipation is a common pediatric issue.
  • Gallbladder motility plays a role in digestion.
  • The relationship between constipation and gallbladder function in children is not well understood.

Purpose of the Study:

  • To evaluate gallbladder motility in children experiencing refractory constipation.
  • To compare gallbladder contractility between constipated children and healthy controls.

Main Methods:

  • A cross-sectional study included 132 constipated children (ages 2-16) and 132 matched controls.
  • Gallbladder contractility was assessed using ultrasonography to measure fasting and postprandial gallbladder areas.
  • A gallbladder contractility index was calculated and compared between groups.

Main Results:

  • Constipated children exhibited significantly larger postprandial gallbladder areas compared to controls (P=.031).
  • The risk of a low gallbladder contractility index (<25%) was 5.2 times higher in constipated children (OR 5.2; 95% CI 2.5-10.81).
  • Older age was associated with a protective effect on gallbladder contractility (OR 0.79; 95% CI 0.71-0.88).

Conclusions:

  • Gallbladder motility disorders are present in children with severe functional constipation.
  • This finding suggests a potential link between gallbladder dysfunction and pediatric functional constipation.
  • Further research may elucidate the role of gallbladder motility in the pathophysiology of childhood constipation.