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Updated: Jul 6, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Major physical and psychological harms of methamphetamine use
Shane Darke1, Sharlene Kaye, Rebecca McKetin
1National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
Issues:
The major physical and psychological health effects of methamphetamine use, and the factors associated with such harms.
Approach:
Comprehensive review.
Key Findings:
Physical harms reviewed included toxicity and mortality, cardiovascular/cerebrovascular pathology, dependence and blood-borne virus transmission. Psychological harms include methamphetamine psychosis, depression, suicide, anxiety and violent behaviours.
Implications:
While high-profile health consequences, such as psychosis, are given prominence in the public debate, the negative sequelae extend far beyond this. This is a drug class that causes serious heart disease, has serious dependence liability and high rates of suicidal behaviours.
Conclusion:
The current public image of methamphetamine does not portray adequately the extensive, and in many cases insidious, harms caused.
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