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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jul 6, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

[Epithelial tissue reconstruction using cell technologies].

A V Vasil'ev, E A Voroteliak, I V Kiselev

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |March 29, 2008
    PubMed
    Summary

    This study explores cellular strategies for skin tissue engineering using human epidermal keratinocytes to create living tissue equivalents for grafting. Data shows successful tissue restoration after transplantation in various medical fields.

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    Published on: October 3, 2014

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    Last Updated: Jul 6, 2026

    Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
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    Published on: February 24, 2016

    Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
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    Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

    Published on: July 10, 2016

    Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
    09:24

    Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

    Published on: October 3, 2014

    Area of Science:

    • Biomedical Engineering
    • Regenerative Medicine
    • Tissue Engineering

    Context:

    • Focuses on the cellular foundations of epithelial tissue engineering, particularly for skin.
    • Addresses the cultivation of human epidermal keratinocytes.
    • Details the creation of living tissue equivalents for therapeutic grafting.

    Purpose:

    • To discuss the principles and applications of skin tissue engineering.
    • To present data on the efficacy of tissue-engineered grafts.
    • To highlight the use of cellular technologies in diverse medical specialties.

    Summary:

    • Describes methods for cultivating human epidermal keratinocytes to form viable tissue equivalents.
    • Presents evidence of successful tissue regeneration following the grafting of these engineered tissues.
    • Illustrates applications in reconstructive surgery, ophthalmology, oncology, and dentistry.

    Impact:

    • Demonstrates the potential of cellular technologies for restoring damaged tissues and organs.
    • Provides insights into the practical use of tissue engineering in clinical settings.
    • Offers a foundation for advancing regenerative medicine approaches.