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The association between conjunctival MALT lymphoma and Helicobacter pylori

Sung-Bok Lee1, Jae-Wook Yang, Chang-Sik Kim

  • 1Department of Ophthalmology, Chungnam National University Hospital, #640 Daesa-dong, Jung-gu, Daejeon 301-721, Korea. kcs61@cnu.ac.kr

The British Journal of Ophthalmology
|March 29, 2008
PubMed
Abstract

Insights

Helicobacter pylori (H pylori) DNA was found in all conjunctival MALT lymphoma cases, suggesting its role in the condition. The vacA s1 allele appears to be a particularly virulent strain associated with this eye lymphoma.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Oncology

Background:

  • Helicobacter pylori (H pylori) is a known cause of gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
  • The potential role of H pylori in conjunctival MALT lymphoma remains to be elucidated.

Purpose of the Study:

  • To investigate the presence of H pylori in conjunctival MALT lymphoma.
  • To identify specific H pylori strains associated with conjunctival MALT lymphoma.

Main Methods:

  • Polymerase chain reaction (PCR) was used to detect H pylori DNA (16S rDNA) in 15 conjunctival MALT lymphoma samples and 8 normal conjunctiva controls.
  • PCR was further employed to analyze virulent genes (vacA s1/2 and vacA m1/2) in H pylori-positive samples.

Main Results:

  • H pylori DNA was detected in all 15 conjunctival MALT lymphoma specimens.
  • No H pylori DNA was found in the control conjunctiva samples.
  • The vacA s1 allele was detected in 11 of the 15 H pylori-positive cases, often with the vacA m2 allele.

Conclusions:

  • H pylori is implicated in the pathogenesis of conjunctival MALT lymphoma.
  • The H pylori vacA s1 allele is identified as a potentially virulent strain associated with conjunctival MALT lymphoma.

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