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Prototyping a large field size IORT applicator for a mobile linear accelerator.

Rogier W J Janssen1, Bruce A Faddegon, Wim J F Dries

  • 1Catharina-Hospital Eindhoven, PO Box 1350, 5602 ZA, Eindhoven, The Netherlands. rogier.janssen@mac.com

Physics in Medicine and Biology
|March 29, 2008
PubMed
Summary

A new rectangular applicator with a scattering foil was developed for intra-operative radiotherapy using the Mobetron, expanding the treatment field size to 80 x 150 mm(2). This innovation simplifies large tumor treatment by providing clinically acceptable dose distributions and accurate Monte Carlo simulations.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Medical Device Design

Background:

  • Intra-operative radiotherapy (IORT) with Mobetron is limited by small applicator fields (max 100 mm diameter).
  • Treating large tumors like sarcomas requires complex techniques due to these field size limitations.

Purpose of the Study:

  • To design and develop a novel rectangular applicator with an enlarged field size (80 x 150 mm(2)) for Mobetron IORT.
  • To improve dose distribution and treatment efficiency for large tumors during IORT.

Main Methods:

  • Utilized EGSnrc Monte Carlo simulation code (BEAMnrc) to model the Mobetron treatment head and design a custom applicator.
  • Developed a prototype rectangular applicator featuring a scattering foil and tested it using diode dosimetry in a water tank.

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  • Validated simulation accuracy against experimental measurements.

    • Main Results:

    • The prototype applicator achieved clinically acceptable 80 x 150 mm(2) dose distributions at 4, 6, and 9 MeV.
    • The new applicator design obviates the need for complex abutting field techniques in IORT.
    • Experimental measurements closely matched Monte Carlo simulations (within 2%/1 mm).

    Conclusions:

    • The developed rectangular applicator effectively expands the treatment field for Mobetron IORT.
    • This advancement offers a more efficient and simpler approach to treating large tumors with intra-operative radiotherapy.
    • The study confirms the accuracy of BEAMnrc Monte Carlo simulations for designing IORT applicators.